Alkaline and acidic hydrolysis of the β-lactam ring
نویسندگان
چکیده
منابع مشابه
Design, synthesis and evaluation of β-lactam antigenic peptide hybrids; unusual opening of the β-lactam ring in acidic media.
β-Lactam peptides were envisioned as conformational constraints in antigenic peptides (APs). Three different β-lactam tripeptides of varying flexibility were prepared in solution and incorporated in place of the central part of the altered melanoma associated antigenic peptide Leu(27)-Melan-A(26-35) using solid phase synthesis techniques. Upon TFA cleavage from the solid support, an unexpected ...
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ژورنال
عنوان ژورنال: Electronic Journal of Theoretical Chemistry
سال: 1997
ISSN: 1082-4928
DOI: 10.1002/ejtc.34